The Sixth meeting of the International Society for the Prevention of Tobacco Induced Diseases (ISPTiD) was held in Little Rock, Arkansas on November 2–4, 2007 and has brought together 140 participants, scientists and experts in this specialized field from 30 countries across the World. The central theme of the conference was the "Translational Approaches to the Prevention of Tobacco Induced Diseases". Discussions held during the three days meeting's sessions (including poster session and platform discussion) promoted a better understanding of the connection between tobacco use and associated medical and health consequences. The Sixth Annual meeting of ISPTiD served as another successful step toward decrease in the huge sociological and economical burden that the entire World is facing with this addiction. The proceedings of the meeting were published in the conference booklet, the ISPTiD global web site and Cancer Database abstract web site. Funds generated from this meeting helped in part to establish the society's Journal "Tobacco Induced Diseases "into the major scientific journal index PubMed database and BioMed Central. The meeting set the tone for next the Annual meeting in Kyoto, Japan for the year 2008 with the theme "Tobacco free future".