RESEARCH PAPER
Analysis of circulating insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 (IGFBP-3) in tobacco smokers and non-smokers
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1
Department of Periodontology and Preventive Dentistry, King's College London, London, UK
 
2
Dental Clinical Research, King's College London, UK
 
3
Department of Oral Biology, University of Manitoba, Canada
 
 
Submission date: 2002-07-02
 
 
Acceptance date: 2002-08-12
 
 
Publication date: 2003-06-15
 
 
Corresponding author
RM Palmer   

Department of Periodontology and Preventive Dentistry, Guy's, Floor 21, Guy's Hospital Tower, King's College London, London, SE1 9RT, UK
 
 
Tobacco Induced Diseases 2003;1(June):157
 
KEYWORDS
ABSTRACT
Background:
IGF-1 and the major serum IGF-1 binding protein, IGFBP-3, are under extensive investigation as potential prognostic markers of specific malignancies and vascular diseases. However, there is conflicting evidence that tobacco smoking may influence systemic concentrations of IGF-1 and IGFBP-3.

Subjects and methods:
Serum concentrations of IGF-1 and IGFBP-3 were measured in 20 smokers and 20 non-smokers, matched for age and gender. Serum concentrations of cotinine, the major metabolite of nicotine, and ICAM-1, known to exhibit a dose-dependent relationship with cotinine, were also assayed.

Results:
There was no difference between the systemic concentrations of IGF-1 or IGFBP-3 found in smokers and non-smokers (IGF-1: mean [s.d]; 104 [29] vs 101 [24] ng ml-1, respectively; and IGFBP-3: 2562 [522] vs 2447 [570] ng ml-1, respectively). Similarly, there was no correlation between serum cotinine and IGF-1 or IGFBP-3 concentrations in smokers. Soluble ICAM-1 concentrations were significantly increased in smokers, compared to non-smokers (mean [s.d]; 258 [60] vs 194 [50] ng ml-1, respectively; p = 0.002).

Conclusions:
There was no relationship noted between tobacco smoking and either IGF-1 or IGFBP-3. These data suggest that smoking would not appear to be a major confounder of the reported clinical associations between IGF-1, IGFBP-3, or IGF-1/IGFBP-3 ratios and specific disease entities.

 
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