Home
Issues
Aims and Scope
Open Access
Editorial Board
Indexing
Why publish with us
Contact us
Instructions to authors (PDF)
Manuscript Types
Manuscript Formatting
How to submit
Preprints
Special Publications & Reprints
Authorship & COI
Principles of Transparency Checklist
Data Policies
Publication Ethics and Publication Malpractice Statement
RESEARCH PAPER
Comparison between cigarette smoke-induced emphysema and cigarette smoke extract-induced emphysema
Jun Cao
4
1
Intensive Care Unit, the Second Xiangya Hospital, Central-South University, Changsha, China
2
Department of Respiratory Medicine, The Second Xiangya Hospital, Central-South University, Changsha, China
3
Division of Respiratory Disease, Department of Internal Medicine, The Second Xiangya Hospital, Central-South University, Changsha, China
4
Department of Respiratory Medicine, Hunan Provincial People’s Hospital, Changsha, China
Submission date: 2014-08-12
Acceptance date: 2015-03-15
Publication date: 2015-03-25
Corresponding author
Ping Chen
Department of Respiratory Medicine, The Second Xiangya Hospital, Central-South University, Changsha, Hunan 410011, China
Department of Respiratory Medicine, The Second Xiangya Hospital, Central-South University, Changsha, Hunan 410011, China
Yan Chen
Division of Respiratory Disease, Department of Internal Medicine, The Second Xiangya Hospital, Central-South University, Changsha, Hunan 410011, China
Division of Respiratory Disease, Department of Internal Medicine, The Second Xiangya Hospital, Central-South University, Changsha, Hunan 410011, China
Tobacco Induced Diseases 2015;13(March):6
KEYWORDS
ABSTRACT
Background:
Emphysema is the main pathological feature of COPD and also is the focus of the related research. Although several emphysema animal models have been established, exact comparison of findings is seldom. The present study aimed to compare cigarette smoke (CS) exposure-induced emphysema model and intraperitoneal injection of cigarette smoke extract (CSE)-induced emphysema model to evaluate the effectiveness of the two different modeling methods.
Methods:
Six-week-old male C57BL/6 J mice were used and randomly divided into two groups: CS exposure and intraperitoneal injection of CSE. Each group was subdivided into two subgroups: control and CS or CSE. Lung function, mean linear intercept (MLI), destructive index (DI), apoptotic index (AI), total and differential cells count in broncholavolar lavage fluid (BALF), SOD and IL-6 concentration in serum were measured.
Results:
Compared with their respective controls, lung function was significantly decreased in CS and CSE groups (P < 0.01); MLI, DI, and AI of lung tissue were significantly higher in CS and CSE groups (P < 0.01); total number of leukocytes, the number and percentage of neutrophils (NEUs), and the number of macrophages (MAC) in BALF were significantly higher in CS and CSE groups (P < 0.01); SOD concentration in serum was significantly decreased in CS and CSE groups (P < 0.01); IL-6 concentration in serum was significantly increased in in CS and CSE groups (P < 0.01). There was no significant difference between CS group and CSE group in any of the parameters described above.
Conclusions:
Both CS exposure and intraperitoneal injection of CSE could induce emphysema and the effectiveness of the two different modeling methods were equal.
Emphysema is the main pathological feature of COPD and also is the focus of the related research. Although several emphysema animal models have been established, exact comparison of findings is seldom. The present study aimed to compare cigarette smoke (CS) exposure-induced emphysema model and intraperitoneal injection of cigarette smoke extract (CSE)-induced emphysema model to evaluate the effectiveness of the two different modeling methods.
Methods:
Six-week-old male C57BL/6 J mice were used and randomly divided into two groups: CS exposure and intraperitoneal injection of CSE. Each group was subdivided into two subgroups: control and CS or CSE. Lung function, mean linear intercept (MLI), destructive index (DI), apoptotic index (AI), total and differential cells count in broncholavolar lavage fluid (BALF), SOD and IL-6 concentration in serum were measured.
Results:
Compared with their respective controls, lung function was significantly decreased in CS and CSE groups (P < 0.01); MLI, DI, and AI of lung tissue were significantly higher in CS and CSE groups (P < 0.01); total number of leukocytes, the number and percentage of neutrophils (NEUs), and the number of macrophages (MAC) in BALF were significantly higher in CS and CSE groups (P < 0.01); SOD concentration in serum was significantly decreased in CS and CSE groups (P < 0.01); IL-6 concentration in serum was significantly increased in in CS and CSE groups (P < 0.01). There was no significant difference between CS group and CSE group in any of the parameters described above.
Conclusions:
Both CS exposure and intraperitoneal injection of CSE could induce emphysema and the effectiveness of the two different modeling methods were equal.
REFERENCES (46)
1.
Fuschillo S, Martucci M, Donner CF, Balzano G. Airway bacterial colonization: the missing link between COPD and cardiovascular events? Respir Med. 2012;106:915–23.
2.
Miravitlles M. Cough and sputum production as risk factors for poor outcomes in patients with COPD. Respir Med. 2011;105:1118–28.
3.
Pryor WA, Stone K. Oxidants in cigarette smoke. Radicals, hydrogen peroxide, peroxynitrate, and peroxynitrite. Ann N Y Acad Sci. 1993;686:12–27.
4.
Xu CB, Lei Y, Chen Q, Pehrson C, Larsson L, Edvinsson L. Cigarette smoke extracts promote vascular smooth muscle cell proliferation and enhances contractile responses in the vasculature and airway. Basic Clin Pharmacol Toxicol. 2010;107:940–8.
5.
Zhang H, Chen P, Zeng H, Zhang Y, Peng H, Chen Y, et al. Protective effect of demethylation treatment on cigarette smoke extract-induced mouse emphysema model. J Pharmacol Sci. 2013;123:159–66.
6.
He S, He Z, Chen Y, Ye J, Zong D, Zhang Y, et al. C-Kit/c-Kit ligand interaction of bone marrow endothelial progenitor cells is influenced in acigarette smoke extract-induced emphysema model. Exp Lung Res. 2013;39:258–67.
7.
World Medical Association; American Physiological Society. Guiding principles for research involving animals and human beings. Am J Physiol Regul Integr Comp Physiol. 2002;283:R281–3.
8.
Chen Y, Hanaoka M, Droma Y, Chen P, Voelkel NF, Kubo K. Endothelin-1 receptor antagonists prevent the development of pulmonary emphysema in rats. Eur Respir J. 2010;35:904–12.
9.
Zhang Y, Cao J, Chen Y, Chen P, Peng H, Cai S, et al. Intraperitoneal injection of cigarette smoke extract induced emphysema, and injury of cardiac and skeletal muscles in BALB/C mice. Exp Lung Res. 2013;39:18–31.
10.
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, et al. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest. 2012;122:2032–45.
11.
Chen Y, Hanaoka M, Chen P, Droma Y, Voelkel NF, Kubo K. Protective effect of beraprost sodium, a stable prostacyclin analog, in the development of cigarette smoke extract-induced emphysema. Am J Physiol Lung Cell Mol Physiol. 2009;296:L648–56.
12.
Vestbo J, Hurd SS, Agustí AG, Jones PW, Vogelmeier C, Anzueto A, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonarydisease: GOLD executive summary. Am J Respir Crit Care Med. 2013;187:347–65.
13.
Wright JL, Cosio M, Churg A. Animal models of chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol. 2008;295:L1–15.
14.
Ochs M. Estimating structural alterations in animal models of lung emphysema. Is there a gold standard? Ann Anat. 2014;196:26–33.
15.
American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1995;152:S77–121.
16.
Yang Q, Underwood MJ, Hsin MK, Liu XC, He GW. Dysfunction of pulmonary vascular endothelium in chronic obstructive pulmonary disease: basic considerations for future drug development. Curr Drug Metab. 2008;9:661–7.
17.
He Z, Chen Y, Chen P, Wu G, Cai S. Local inflammation occurs before systemic inflammation in patients with COPD. Respirology. 2010;15:478–84.
18.
Yao H, Rahman I. Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease. Toxicol Appl Pharmacol. 2011;254:72–85.
19.
Hillas G, Nikolakopoulou S, Hussain S, Vassilakopoulos T. Antioxidants and mucolytics in COPD management: when (if ever) and in whom? Curr Drug Targets. 2013;14:225–34.
20.
Yao H, Arunachalam G, Hwang JW, Chung S, Sundar IK, Kinnula VL, et al. Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM. Proc Natl Acad Sci U S A. 2010;107:15571–6.
21.
Biffl WL, Moore EE, Moore FA, Barnett Jr CC, Carl VS, Peterson VN. Interleukin-6 delays neutrophil apoptosis. Arch Surg. 1996;131:24–30.
22.
Yanbaeva DG, Dentener MA, Spruit MA, Houwing-Duistermaat JJ, Kotz D, Passos VL, et al. IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case–control study. BMC Med Genet. 2009;10:23.
23.
Ruwanpura SM, McLeod L, Miller A, Jones J, Bozinovski S, Vlahos R, et al. Interleukin-6 promotes pulmonary emphysema associated with apoptosis in mice. Am J Respir Cell Mol Biol. 2011;45:720–30.
24.
Bozinovski S, Hutchinson A, Thompson M, Macgregor L, Black J, Giannakis E, et al. Serum amyloid a is a biomarker of acute exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2008;177:269–78.
25.
Martin JG, Tamaoka M. Rat models of asthma and chronic obstructive lung disease. Pulm Pharmacol Ther. 2006;19:377–85.
26.
Brusselle GG, Bracke KR, Maes T, D’hulst AI, Moerloose KB, Joos GF, et al. Murine models of COPD. Pulm Pharmacol Ther. 2006;19:155–65.
27.
Plopper CG, Hyde DM. The non-human primate as a model for studying COPD and asthma. Pulm Pharmacol Ther. 2008;21:755–66.
28.
Chapman RW. Canine models of asthma and COPD. Pulm Pharmacol Ther. 2008;21:731–42.
29.
Abraham WM. Modeling of asthma, COPD and cystic fibrosis in sheep. Pulm Pharmacol Ther. 2008;21:743–54.
30.
Mahadeva R, Shapiro SD. Chronic obstructive pulmonary disease * 3: experimental animal models of pulmonary emphysema. Thorax. 2002;57:908–14.
31.
Wright JL, Churg A. Animal models of cigarette smoke-induced COPD. Chest. 2002;122(6 suppl):S301–6.
32.
Givi ME, Peck MJ, Boon L, Mortaz E. The role of dendritic cells in the pathogenesis of cigarette smoke-induced emphysema in mice. Eur J Pharmacol. 2013;721:259–66.
33.
Longhini-Dos-Santos N, Barbosa-de-Oliveira VA, Kozma RH, Faria CA, Stessuk T, Frei F, et al. Cell therapy with bone marrow mononuclear cells in elastase-induced pulmonary emphysema. Stem Cell Rev. 2013;9:210–8.
34.
Pera T, Zuidhof AB, Smit M, Menzen MH, Klein T, Flik G, et al. Arginase inhibition prevents inflammation and remodeling in a guinea pig model of chronic obstructive pulmonary disease. J Pharmacol Exp Ther. 2014;349:229–38.
35.
Wagner U, Staats P, Fehmann HC, Fischer A, Welte T, Groneberg DA. Analysis of airway secretions in a model of sulfur dioxide induced chronic obstructive pulmonary disease (COPD). J Occup Med Toxicol. 2006;1:12.
36.
Misaka S, Sato H, Yamauchi Y, Onoue S, Yamada S. Novel dry powder formulation of ovalbumin for development of COPD-like animal model: physicochemical characterization and biomarker profiling in rats. Eur J Pharm Sci. 2009;37:469–76.
37.
Tazaki G, Kondo T, Tajiri S, Tsuji C, Shioya S, Tanigaki T. Functional residual capacity and airway resistance in rats of COPD model induced by systemic hyaluronidase. Tokai J Exp Clin Med. 2006;31:125–7.
38.
Baron RM, Choi AJ, Owen CA, Choi AM. Genetically manipulated mouse models of lung disease: potential and pitfalls. Am J Physiol Lung Cell Mol Physiol. 2012;302:L485–97.
39.
Taraseviciene-Stewart L, Scerbavicius R, Choe KH, Moore M, Sullivan A, Nicolls MR, et al. An animal model of autoimmune emphysema. Am J Respir Crit Care Med. 2005;171:734–42.
40.
Pennisi E. Genomics: sequence tells mouse, human genome secrets. Science. 2002;298:1863–5.
41.
Jeong YY, Park HJ, Cho YW, Kim EJ, Kim GT, Mun YJ, et al. Aged red garlic extract reduces cigarette smoke extract-induced cell death in human bronchial smooth muscle cells by increasing intracellular glutathione levels. Phytother Res. 2012;26:18–25.
42.
Tzortzaki EG, Papi A, Neofytou E, Soulitzis N, Siafakas NM. Immune and genetic mechanisms in COPD: possible targets for therapeutic interventions. Curr Drug Targets. 2013;14:141–8.
43.
He ZH, Chen P, Chen Y, Zhu YQ, He SD, Ye JR, et al. Dual effects of cigarette smoke extract on proliferation of endothelial progenitor cells and the protective effect of 5-aza-2’-deoxycytidine on EPCs against the damage caused by CSE. BioMed Res Int. 2014;2014:640752.
44.
Nana-Sinkam SP, Lee JD, Sotto-Santiago S, Stearman RS, Keith RL, Choudhury Q, et al. Prostacyclin prevents pulmonary endothelial cell apoptosis induced by cigarette smoke. Am J Respir Crit Care Med. 2007;175:676–85.
45.
Taraseviciene-Stewart L, Kraskauskas D, Lee JH, Hanaoka M, Burns N, Parr J, et al. Cigarette smoke extract (CSE)-induced emphysema in mice. Am J Respir Crit Care Med. 2007;175:A529.
46.
Yao H, Edirisinghe I, Rajendrasozhan S, Yang SR, Caito S, Adenuga D, et al. Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice. Am J Physiol Lung Cell Mol Physiol. 2008;294:L1174–86.
CITATIONS (49):
1.
Tumor necrosis factor-like weak inducer of apoptosis regulates quadriceps muscle atrophy and fiber-type alteration in a rat model of chronic obstructive pulmonary disease
Jun-Juan Lu, Qing Wang, Li Hua Xie, Qiang Zhang, Sheng Hua Sun
Tobacco Induced Diseases
Jun-Juan Lu, Qing Wang, Li Hua Xie, Qiang Zhang, Sheng Hua Sun
Tobacco Induced Diseases
2.
miR-34a is involved in CSE-induced apoptosis of human pulmonary microvascular endothelial cells by targeting Notch-1 receptor protein
Ying-Jiao Long, Xiao-Peng Liu, Shan-Shan Chen, Dan-Dan Zong, Yan Chen, Ping Chen
Respiratory Research
Ying-Jiao Long, Xiao-Peng Liu, Shan-Shan Chen, Dan-Dan Zong, Yan Chen, Ping Chen
Respiratory Research
3.
PTEN/PI3k/AKT Regulates Macrophage Polarization in Emphysematous mice
J. Lu, L. Xie, C. Liu, Q. Zhang, S. Sun
Scandinavian Journal of Immunology
J. Lu, L. Xie, C. Liu, Q. Zhang, S. Sun
Scandinavian Journal of Immunology
4.
l-Menthol alleviates cigarette smoke extract induced lung injury in rats by inhibiting oxidative stress and inflammation via nuclear factor kappa B, p38 MAPK and Nrf2 signalling pathways
Yan Liu, Ang Li, Xiuli Feng, Xiaoyan Jiang, Xiao Sun, Weizhen Huang, Xiaosong Zhu, Zhongxi Zhao
RSC Advances
Yan Liu, Ang Li, Xiuli Feng, Xiaoyan Jiang, Xiao Sun, Weizhen Huang, Xiaosong Zhu, Zhongxi Zhao
RSC Advances
5.
Pharmacological Investigation of the Anti-Inflammation and Anti-Oxidation Activities of Diallyl Disulfide in a Rat Emphysema Model Induced by Cigarette Smoke Extract
Yan Liu, Ang Li, Xiuli Feng, Xiao Sun, Xiaosong Zhu, Zhongxi Zhao
Nutrients
Yan Liu, Ang Li, Xiuli Feng, Xiao Sun, Xiaosong Zhu, Zhongxi Zhao
Nutrients
6.
MicroRNA-21 aggravates chronic obstructive pulmonary disease by promoting autophagy
Zhengpeng Zeng, ShengYang He, JunJuan Lu, Chun Liu, Hua Lin, ChaoQun Xu, LiHua Xie, ShengHua Sun
Experimental Lung Research
Zhengpeng Zeng, ShengYang He, JunJuan Lu, Chun Liu, Hua Lin, ChaoQun Xu, LiHua Xie, ShengHua Sun
Experimental Lung Research
7.
Tobacco-Free Cigarette Smoke Exposure Induces Anxiety and Panic-Related Behaviours in Male Wistar Rats
Máira Tereza Talma Chírico, Frank Silva Bezerra, Mariana Reis Guedes, Ana Beatriz Souza, Fernanda Cacilda Silva, Glenda Campos, Sylvana Rendeiro de Noronha, Laura Batista Tavares Mesquita, Thayane Oliveira Reis, Silvia Dantas Cangussú, Deoclécio Alves Chianca-Jr, Rodrigo Cunha de Menezes
Scientific Reports
Máira Tereza Talma Chírico, Frank Silva Bezerra, Mariana Reis Guedes, Ana Beatriz Souza, Fernanda Cacilda Silva, Glenda Campos, Sylvana Rendeiro de Noronha, Laura Batista Tavares Mesquita, Thayane Oliveira Reis, Silvia Dantas Cangussú, Deoclécio Alves Chianca-Jr, Rodrigo Cunha de Menezes
Scientific Reports
8.
Protective effect of methylallyl sulfone in the development of cigarette smoke extract-induced apoptosis in rats and HFL-1 cells
Ang Li, Yan Liu, Xiaosong Zhu, Xiao Sun, Xiuli Feng, Dawei Li, Jiangqiang Zhang, Meihua Zhu, Zhongxi Zhao
Biochemical and Biophysical Research Communications
Ang Li, Yan Liu, Xiaosong Zhu, Xiao Sun, Xiuli Feng, Dawei Li, Jiangqiang Zhang, Meihua Zhu, Zhongxi Zhao
Biochemical and Biophysical Research Communications
9.
A Novel Murine Chronic Obstructive Pulmonary Disease Model and the Pathogenic Role of MicroRNA-21
Shengyang He, Liqiu Li, Shenghua Sun, Zhengpeng Zeng, Junjuan Lu, Lihua Xie
Frontiers in Physiology
Shengyang He, Liqiu Li, Shenghua Sun, Zhengpeng Zeng, Junjuan Lu, Lihua Xie
Frontiers in Physiology
10.
Methylallyl sulfone attenuates inflammation, oxidative stress and lung injury induced by cigarette smoke extract in mice and RAW264.7 cells
Ang Li, Yan Liu, Xiaosong Zhu, Xiao Sun, Xiuli Feng, Dawei Li, Jiangqiang Zhang, Meihua Zhu, Zhongxi Zhao
International Immunopharmacology
Ang Li, Yan Liu, Xiaosong Zhu, Xiao Sun, Xiuli Feng, Dawei Li, Jiangqiang Zhang, Meihua Zhu, Zhongxi Zhao
International Immunopharmacology
11.
Endothelial Progenitor Cells as Pathogenetic and Diagnostic Factors, and Potential Targets for GLP-1 in Combination with Metabolic Syndrome and Chronic Obstructive Pulmonary Disease
Evgenii Skurikhin, Olga Pershina, Angelina Pakhomova, Edgar Pan, Vyacheslav Krupin, Natalia Ermakova, Olga Vaizova, Anna Pozdeeva, Mariia Zhukova, Viktoriia Skurikhina, Wolf-Dieter Grimm, Alexander Dygai
International Journal of Molecular Sciences
Evgenii Skurikhin, Olga Pershina, Angelina Pakhomova, Edgar Pan, Vyacheslav Krupin, Natalia Ermakova, Olga Vaizova, Anna Pozdeeva, Mariia Zhukova, Viktoriia Skurikhina, Wolf-Dieter Grimm, Alexander Dygai
International Journal of Molecular Sciences
12.
Notch promotes DNMT-mediated hypermethylation of Klotho leads to COPD-related inflammation
Jie Qiu, Ya-Nan Zhang, Xiwei Zheng, Peng Zhang, Gang Ma, Hai Tan
Experimental Lung Research
Jie Qiu, Ya-Nan Zhang, Xiwei Zheng, Peng Zhang, Gang Ma, Hai Tan
Experimental Lung Research
13.
Correlation analysis between depression and family fitness in chronic obstructive pulmonary disease inpatients
Xuexue Deng, Jinping Song
Medicine
Xuexue Deng, Jinping Song
Medicine
14.
Lycopene mitigates pulmonary emphysema induced by cigarette smoke in a murine model
Keila Campos, Oliveira de, Thais Martins, Guilherme Costa, André Talvani, Camila Garcia, Laser Oliveira, Sílvia Cangussú, Daniela Costa, Frank Bezerra
The Journal of Nutritional Biochemistry
Keila Campos, Oliveira de, Thais Martins, Guilherme Costa, André Talvani, Camila Garcia, Laser Oliveira, Sílvia Cangussú, Daniela Costa, Frank Bezerra
The Journal of Nutritional Biochemistry
15.
Ergosterol attenuates cigarette smoke extract-induced COPD by modulating inflammation, oxidative stress and apoptosis in vitro and in vivo
Xiao Sun, Xiuli Feng, Dandan Zheng, Ang Li, Chunyan Li, Siying Li, Zhongxi Zhao
Clinical Science
Xiao Sun, Xiuli Feng, Dandan Zheng, Ang Li, Chunyan Li, Siying Li, Zhongxi Zhao
Clinical Science
16.
Protective effect of autophagy on endoplasmic reticulum stress induced apoptosis of alveolar epithelial cells in rat models of COPD
Yao Tang, Qi-Hang Cai, Yong-Jian Wang, Shao-Hua Fan, Zi-Feng Zhang, Meng-Qi Xiao, Jin-Yu Zhu, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng
Bioscience Reports
Yao Tang, Qi-Hang Cai, Yong-Jian Wang, Shao-Hua Fan, Zi-Feng Zhang, Meng-Qi Xiao, Jin-Yu Zhu, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng
Bioscience Reports
17.
Ablation of Arf-expressing cells ameliorates cigarette smoke-induced lung dysfunction in mice
Ryuta Mikawa, Tadashi Sato, Yohei Suzuki, Hario Baskoro, Masataka Sugimoto
Ryuta Mikawa, Tadashi Sato, Yohei Suzuki, Hario Baskoro, Masataka Sugimoto
19.
Gender Differences in the Pharmacological Actions of Pegylated Glucagon-Like Peptide-1 on Endothelial Progenitor Cells and Angiogenic Precursor Cells in a Combination of Metabolic Disorders and Lung Emphysema
Pershina, Pakhomova, Widera, Ermakova, Epanchintsev, Pan, Krupin, Vaizova, Putrova, Sandrikina, Kurochkina, Morozov, Kubatiev, Dygai, Skurikhin
International Journal of Molecular Sciences
Pershina, Pakhomova, Widera, Ermakova, Epanchintsev, Pan, Krupin, Vaizova, Putrova, Sandrikina, Kurochkina, Morozov, Kubatiev, Dygai, Skurikhin
International Journal of Molecular Sciences
20.
PRMT6 mediates inflammation via activation of the NF-κB/
p65 pathway on a cigarette smoke extract-induced murine
emphysema model
Xue He, Tiao Li, Lijuan Luo, Huihui Zeng, Yan Chen, Shan Cai
Tobacco Induced Diseases
Xue He, Tiao Li, Lijuan Luo, Huihui Zeng, Yan Chen, Shan Cai
Tobacco Induced Diseases
21.
A High-Throughput System for Cyclic Stretching of Precision-Cut Lung Slices During Acute Cigarette Smoke Extract Exposure
Jarred Mondoñedo, Elizabeth Bartolák-Suki, Jawde Bou, Kara Nelson, Kun Cao, Adam Sonnenberg, Walter Obrochta, Jasmin Imsirovic, Sumati Ram-Mohan, Ramaswamy Krishnan, Béla Suki
Frontiers in Physiology
Jarred Mondoñedo, Elizabeth Bartolák-Suki, Jawde Bou, Kara Nelson, Kun Cao, Adam Sonnenberg, Walter Obrochta, Jasmin Imsirovic, Sumati Ram-Mohan, Ramaswamy Krishnan, Béla Suki
Frontiers in Physiology
22.
p19Arf Exacerbates Cigarette Smoke-Induced Pulmonary Dysfunction
Ryuta Mikawa, Tadashi Sato, Yohei Suzuki, Hario Baskoro, Koichiro Kawaguchi, Masataka Sugimoto
Biomolecules
Ryuta Mikawa, Tadashi Sato, Yohei Suzuki, Hario Baskoro, Koichiro Kawaguchi, Masataka Sugimoto
Biomolecules
23.
Cigarette smoke extract triggers neoplastic change in lungs and impairs locomotor activity through wnt3a-β-catenin signaling in aged COPD rodent model
Kusum Devi, Baisakhi Moharana
Experimental Lung Research
Kusum Devi, Baisakhi Moharana
Experimental Lung Research
24.
Beneficial Effects of Naringenin in Cigarette Smoke-Induced Damage to the Lung Based on Bioinformatic Prediction and In Vitro Analysis
Pan Chen, Ziting Xiao, Hao Wu, Yonggang Wang, Weiyang Fan, Weiwei Su, Peibo Li
Molecules
Pan Chen, Ziting Xiao, Hao Wu, Yonggang Wang, Weiyang Fan, Weiwei Su, Peibo Li
Molecules
25.
The impact of periodontitis in the course of chronic obstructive pulmonary disease: Pulmonary and systemic effects
Ellen Rosa, Felipe Murakami-Malaquias-da-Silva, Marlon Palma-Cruz, Carvalho de, Auriléia Brito, Lucas Andreo, Sergio Kamei, Renata Negreiros, Maria Rodrigues, Raquel Mesquita-Ferrari, Sandra Bussadori, Kristianne Fernandes, Ana Ligeiro-de-Oliveira, Adriana Lino-Dos-Santos-Franco, Anna Horliana
Life Sciences
Ellen Rosa, Felipe Murakami-Malaquias-da-Silva, Marlon Palma-Cruz, Carvalho de, Auriléia Brito, Lucas Andreo, Sergio Kamei, Renata Negreiros, Maria Rodrigues, Raquel Mesquita-Ferrari, Sandra Bussadori, Kristianne Fernandes, Ana Ligeiro-de-Oliveira, Adriana Lino-Dos-Santos-Franco, Anna Horliana
Life Sciences
26.
Human umbilical cord mesenchymal stem cell-derived extracellular vesicles ameliorate airway inflammation in a rat model of chronic obstructive pulmonary disease (COPD)
Noridzzaida Ridzuan, Norashikin Zakaria, Darius Widera, Jonathan Sheard, Mitsuru Morimoto, Hirofumi Kiyokawa, Isa Mohd, Singh Chatar, Kong-Yong Then, Ghee-Chien Ooi, Badrul Yahaya
Stem Cell Research & Therapy
Noridzzaida Ridzuan, Norashikin Zakaria, Darius Widera, Jonathan Sheard, Mitsuru Morimoto, Hirofumi Kiyokawa, Isa Mohd, Singh Chatar, Kong-Yong Then, Ghee-Chien Ooi, Badrul Yahaya
Stem Cell Research & Therapy
27.
Gut microbiota modulates COPD pathogenesis: role of anti-inflammatory Parabacteroides goldsteinii lipopolysaccharide
Hsin-Chih Lai, Tzu-Lung Lin, Ting-Wen Chen, Yu-Lun Kuo, Chih-Jung Chang, Tsung-Ru Wu, Ching-Chung Shu, Ying-Huang Tsai, Simon Swift, Chia-Chen Lu
Gut
Hsin-Chih Lai, Tzu-Lung Lin, Ting-Wen Chen, Yu-Lun Kuo, Chih-Jung Chang, Tsung-Ru Wu, Ching-Chung Shu, Ying-Huang Tsai, Simon Swift, Chia-Chen Lu
Gut
28.
Oxidative stress links the tumour suppressor p53 with cell apoptosis induced by cigarette smoke
Qing Song, Zi-Jing Zhou, Shan Cai, Yan Chen, Ping Chen
International Journal of Environmental Health Research
Qing Song, Zi-Jing Zhou, Shan Cai, Yan Chen, Ping Chen
International Journal of Environmental Health Research
29.
Airway-On-A-Chip: Designs and Applications for Lung Repair and Disease
Tanya Bennet, Avineet Randhawa, Jessica Hua, Karen Cheung
Cells
Tanya Bennet, Avineet Randhawa, Jessica Hua, Karen Cheung
Cells
30.
The inhibitor miR-21 regulates macrophage polarization in
an experimental model of chronic obstructive pulmonary
disease
JunJuan Lu, LiHua Xie, ShengHua Sun
Tobacco Induced Diseases
JunJuan Lu, LiHua Xie, ShengHua Sun
Tobacco Induced Diseases
31.
Existence of multiple organ aging in animal model of
emphysema induced by cigarette smoke extract
Guibin Liang, Zhihui He, Yan Chen, Hongbo Zhang, Huaihuai Peng, Dandan Zong, Yingjiao Long
Tobacco Induced Diseases
Guibin Liang, Zhihui He, Yan Chen, Hongbo Zhang, Huaihuai Peng, Dandan Zong, Yingjiao Long
Tobacco Induced Diseases
32.
Spiperone Stimulates Regeneration in Pulmonary Endothelium Damaged by Cigarette Smoke and Lipopolysaccharide
Evgenii Skurikhin, Olga Pershina, Mariia Zhukova, Darius Widera, Edgar Pan, Angelina Pakhomova, Vyacheslav Krupin, Natalia Ermakova, Victoria Skurikhina, Lubov Sandrikina, Sergey Morozov, Aslan Kubatiev, Alexander Dygai
International Journal of Chronic Obstructive Pulmonary Disease
Evgenii Skurikhin, Olga Pershina, Mariia Zhukova, Darius Widera, Edgar Pan, Angelina Pakhomova, Vyacheslav Krupin, Natalia Ermakova, Victoria Skurikhina, Lubov Sandrikina, Sergey Morozov, Aslan Kubatiev, Alexander Dygai
International Journal of Chronic Obstructive Pulmonary Disease
33.
Aurintricarboxylic acid mitigates cigarette smoke extract induced oxidative stress and pulmonary inflammation via inhibition of NF-ҡB/p65 signaling
Kusum Devi, Yatendra Singh, Sanjeev Kanojiya, Baisakhi Moharana
Toxicology Mechanisms and Methods
Kusum Devi, Yatendra Singh, Sanjeev Kanojiya, Baisakhi Moharana
Toxicology Mechanisms and Methods
34.
Prohibitin Protects Pulmonary Microvascular Endothelial Cells Against Cigarette Smoke Extract-Induced Cell Apoptosis and Inflammation
Yating Peng, Wei Cheng, Jiaxi Duan, Yiyang Zhao, Zijing Zhou, Aiyuan Zhou, Minhua Deng, Hong Peng, Ruoyun Ouyang, Yan Chen, Ping Chen
International Journal of Chronic Obstructive Pulmonary Disease
Yating Peng, Wei Cheng, Jiaxi Duan, Yiyang Zhao, Zijing Zhou, Aiyuan Zhou, Minhua Deng, Hong Peng, Ruoyun Ouyang, Yan Chen, Ping Chen
International Journal of Chronic Obstructive Pulmonary Disease
35.
Multi-omics analyses of airway host–microbe interactions in chronic obstructive pulmonary disease identify potential therapeutic interventions
Zhengzheng Yan, Boxuan Chen, Yuqiong Yang, Xinzhu Yi, Mingyuan Wei, Gertrude Ecklu-Mensah, Mary Buschmann, Haiyue Liu, Jingyuan Gao, Weijie Liang, Xiaomin Liu, Junhao Yang, Wei Ma, Zhenyu Liang, Fengyan Wang, Dandan Chen, Lingwei Wang, Weijuan Shi, Martin Stampfli, Pan Li, Shenhai Gong, Xia Chen, Wensheng Shu, Emad El-Omar, Jack Gilbert, Martin Blaser, Hongwei Zhou, Rongchang Chen, Zhang Wang
Nature Microbiology
Zhengzheng Yan, Boxuan Chen, Yuqiong Yang, Xinzhu Yi, Mingyuan Wei, Gertrude Ecklu-Mensah, Mary Buschmann, Haiyue Liu, Jingyuan Gao, Weijie Liang, Xiaomin Liu, Junhao Yang, Wei Ma, Zhenyu Liang, Fengyan Wang, Dandan Chen, Lingwei Wang, Weijuan Shi, Martin Stampfli, Pan Li, Shenhai Gong, Xia Chen, Wensheng Shu, Emad El-Omar, Jack Gilbert, Martin Blaser, Hongwei Zhou, Rongchang Chen, Zhang Wang
Nature Microbiology
36.
Identification and Analysis of Necroptosis-Related Genes in COPD by Bioinformatics and Experimental Verification
Yingxi Wang, Xin Su, Yan Yin, Qiuyue Wang
Biomolecules
Yingxi Wang, Xin Su, Yan Yin, Qiuyue Wang
Biomolecules
37.
MFG-E8 stabilized by deubiquitinase USP14 suppresses cigarette smoke-induced ferroptosis in bronchial epithelial cells
Yanan Cui, Lijuan Luo, Zihang Zeng, Xiangming Liu, Tiao Li, Xue He, Yiming Ma, Weiwei Meng, Huihui Zeng, Yingjiao Long, Dandan Zong, Yan Chen
Cell Death & Disease
Yanan Cui, Lijuan Luo, Zihang Zeng, Xiangming Liu, Tiao Li, Xue He, Yiming Ma, Weiwei Meng, Huihui Zeng, Yingjiao Long, Dandan Zong, Yan Chen
Cell Death & Disease
38.
GSPE attenuates CSE-induced lung inflammation and emphysema by regulating autophagy via the reactive oxygen species/TFEB signaling pathway
Ok Sul, Hye Choi, Jimi Oh, Seung Ra
Food and Chemical Toxicology
Ok Sul, Hye Choi, Jimi Oh, Seung Ra
Food and Chemical Toxicology
39.
MiR-216a reduces apoptosis of pulmonary microvascular
endothelial cells in COPD by targeting DNMT1
Ling Lin, Qing Song, Wei Cheng, Cong Liu, Aiyuan Zhou, Zijing Zhou, Ping Chen
Tobacco Induced Diseases
Ling Lin, Qing Song, Wei Cheng, Cong Liu, Aiyuan Zhou, Zijing Zhou, Ping Chen
Tobacco Induced Diseases
40.
Grape seed proanthocyanidin extract modulates cigarette smoke extract-induced epithelial cell apoptosis by inhibiting oxidative stress in chronic obstructive pulmonary disease
Ok Joo Sul, Hye Won Choi, Seung Won Ra
Journal of Functional Foods
Ok Joo Sul, Hye Won Choi, Seung Won Ra
Journal of Functional Foods
41.
Rice Bran Oil Improves Emphysema in Cigarette Smoke Extract-Induced Mice through Anti-Inflammatory and Antioxidative Effects
Aikkarach Kettawan, Sukpattaraporn Ruangklai, Thanaporn Rungruang, Julalux Thongam, Aurawan Kringkasemsee Kettawan, Nilesh Nirmal, Sorachai Srisuma
Nutrients
Aikkarach Kettawan, Sukpattaraporn Ruangklai, Thanaporn Rungruang, Julalux Thongam, Aurawan Kringkasemsee Kettawan, Nilesh Nirmal, Sorachai Srisuma
Nutrients
42.
TET2 stabilized by deubiquitinase USP21 ameliorates cigarette smoke-induced apoptosis in airway epithelial cells
Lijuan Luo, Zihang Zeng, Tiao Li, Xiangming Liu, Yanan Cui, Yongguang Tao, Yi Li, Yan Chen
iScience
Lijuan Luo, Zihang Zeng, Tiao Li, Xiangming Liu, Yanan Cui, Yongguang Tao, Yi Li, Yan Chen
iScience
43.
NADH Intraperitoneal Injection Prevents Lung Inflammation in a BALB/C Mice Model of Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease
Nada Slama, Amina Abdellatif, Karima Bahria, Sara Gasmi, Maamar Khames, Abderrahmene Hadji, George Birkmayer, Mustapha Oumouna, Yassine Amrani, Karine Benachour
Cells
Nada Slama, Amina Abdellatif, Karima Bahria, Sara Gasmi, Maamar Khames, Abderrahmene Hadji, George Birkmayer, Mustapha Oumouna, Yassine Amrani, Karine Benachour
Cells
44.
Tobacco toxins trigger bone marrow mesenchymal stem cells aging by inhibiting mitophagy
Kai Xiang, Mingxing Ren, Fengyi Liu, Yuzhou Li, Ping He, Xuerui Gong, Tao Chen, Tianli Wu, Ziyu Huang, Hui She, Kehao Liu, Zheng Jing, Sheng Yang
Ecotoxicology and Environmental Safety
Kai Xiang, Mingxing Ren, Fengyi Liu, Yuzhou Li, Ping He, Xuerui Gong, Tao Chen, Tianli Wu, Ziyu Huang, Hui She, Kehao Liu, Zheng Jing, Sheng Yang
Ecotoxicology and Environmental Safety
45.
LRG1 promotes the apoptosis of pulmonary microvascular endothelial cells through KLK10 in chronic obstructive pulmonary disease
Wei Cheng, Qing Song, Aiyuan Zhou, Ling Lin, Yiyang Zhao, Jiaxi Duan, Zijing Zhou, Yating Peng, Cong Liu, Yuqin Zeng, Ping Chen
Tobacco Induced Diseases
Wei Cheng, Qing Song, Aiyuan Zhou, Ling Lin, Yiyang Zhao, Jiaxi Duan, Zijing Zhou, Yating Peng, Cong Liu, Yuqin Zeng, Ping Chen
Tobacco Induced Diseases
46.
Effect of photobiomodulation in the balance between effector and regulatory T cells in an experimental model of COPD
Auriléia Aparecida de Brito, Karine Zanella Herculano, Cristiano Rodrigo de Alvarenga-Nascimento, Cintia Estefano-Alves, Cinthya Cosme Gutierrez Duran, Rodrigo Labat Marcos, José Antonio Silva Junior, Maria Cristina Chavantes, Stella Regina Zamuner, Flávio Aimbire, Laia Lladó-Pelfort, Albert Gubern, Anna Fàbrega, Renata Kelly da Palma, Ana Paula Ligeiro de Oliveira
Frontiers in Medicine
Auriléia Aparecida de Brito, Karine Zanella Herculano, Cristiano Rodrigo de Alvarenga-Nascimento, Cintia Estefano-Alves, Cinthya Cosme Gutierrez Duran, Rodrigo Labat Marcos, José Antonio Silva Junior, Maria Cristina Chavantes, Stella Regina Zamuner, Flávio Aimbire, Laia Lladó-Pelfort, Albert Gubern, Anna Fàbrega, Renata Kelly da Palma, Ana Paula Ligeiro de Oliveira
Frontiers in Medicine
47.
The role and mechanism of macrophage autophagy in the experimental model of chronic obstructive pulmonary disease
Li Zhang, Tian Cheng, CaiHong Liu, ShengYang He, JunJuan Lu
Tobacco Induced Diseases
Li Zhang, Tian Cheng, CaiHong Liu, ShengYang He, JunJuan Lu
Tobacco Induced Diseases
48.
Influence and distinctions of particulate matter exposure across varying etiotypes in chronic obstructive pulmonary disease (COPD) mouse model
Jung Hur, Chin Kook Rhee, Hyoung Kyu Yoon, Chan Kwon Park, Jeong Uk Lim, Tai Joon An, Joon Young Choi, Yong Suk Jo
Journal of Inflammation
Jung Hur, Chin Kook Rhee, Hyoung Kyu Yoon, Chan Kwon Park, Jeong Uk Lim, Tai Joon An, Joon Young Choi, Yong Suk Jo
Journal of Inflammation
49.
NFIL3/Tim3 axis regulates effector Th1 inflammation in COPD mice
Junyi Ke, Shu Huang, Zhixiong He, Siyu Lei, Shiya Lin, Yinying Li, Qiuming Li, Hui Huang, Hongchun Huang, Huajiao Qin, Minchao Duan
Frontiers in Immunology
Junyi Ke, Shu Huang, Zhixiong He, Siyu Lei, Shiya Lin, Yinying Li, Qiuming Li, Hui Huang, Hongchun Huang, Huajiao Qin, Minchao Duan
Frontiers in Immunology
Share
RELATED ARTICLE
| eISSN: | 1617-9625 |
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
