Japan is a country with a large sales volume of Heated tobacco products (HTPs) in the world. The reason was widely recognized by the introduction of IQOS in Japan's famous TV show in 2016. And more, electronic cigarettes containing nicotine are hardly widespread because they need to be marketed as pharmaceuticals in Japan. Since the heating temperature of the HTPs is controlled to be lower than the combustion temperature of cigarette, generation of harmful chemical substances is also suppressed. HTPs such as glo and Ploom TECH were sold one after another after IQOS which was put on the Japanese market from Philip Morris International in 2014. From the second half of 2018, new heated tobacco products such as IQOS 3.0, Ploom S, Ploom TECH + and PULZE have been introduced to the Japanese market. In this study, we also analyzed harmful chemical compounds newly generated from IQOS, glo, and Ploom TECH. IQOS tobacco sticks, glo and Ploom TECH were purchased from the Japanese market. Mainstream aerosol from HTPs were collected on a Borgwaldt linear smoking machine model LM4E. The collected aerosol was analyzed tar, nicotine, carbon monoxide (CO), tobacco specific nitrosamine (TSNAs) and polycyclic aromatic hydrocarbon (PAHs). The smoking regime adopted the Health Canada Intense method. The amount of nicotine in HTPs was comparable to that of cigarettes. The amounts of CO, TSNAs and PAHs were reduced compared to cigarettes. However, the number of harmful chemicals has not been reduced. HTPs are tobacco products that heat tobacco filler using electric device. The mainstream aerosol of HTPs contained some harmful constituents as cigarettes. The amounts of harmful constituents from HTP decreased than cigarette by smoking regime, however HTP smoking proved the combined exposure by many harmful constituents and some carcinogens.