Aim:
The aim of this study is to investigate the effecets of diode laser decontamination as an adjunct to non-surgical periodontal treatment on the clinical periodontal and biochemical parameters in smokers and non-smokers with chronic periodontitis.

Material and Methods:
The study group was consisted of 15 smokers and 15 non-smokers systemically healthy 30 volunteers who had been diagnosed with chronic periodontitis. Prior to periodontal treatment, probing depth (PD), clinical attachment level (CAL), plaque index (PI), gingival index (GI) and bleeding on probing (BOP) were recorded. After GCF sampled in split mouth design, scaling and root planing was performed and then diode laser was applied. After the treatment, clinical periodontal measurements and GCF samplings were repeated on the 1st and 3rd months. The GCF levels of IL-8 and TNF-α were determined by ELISA.

Results:
Statistical analysis of data revealed that clinical parameters showed statistically significant reduction in all treatment groups at the end of 3rd mounth (p< 0.05). The reduction in PD, CAL and GI parameters were found to be more statistically significant in laser group than the control group in smokers and non-smokers (p< 0.05). The changes of the biochemical parameters showed no statistically significance between test and control groups in smokers and non-smokers (p>0.05).

Conclusions:
It was concluded that pocket decontamination with diode laser adjunct to non-surgical periodontal treatment has additional benefits on clinical periodontal parameters; but have no additional benefit in terms of the reductions in biochemical parameters in smokers and non-smokers with chronic periodontitis patients.