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CONFERENCE PROCEEDING
Effect of smoking on salivary free amino acid levels
1
Department of Periodontology, Faculty of Dentistry, Ankara University, Ankara, Turkey
2
Department of Medical Biochemistry, School of Medicine, Acıbadem University, Ankara, Turkey
Publication date: 2018-10-03
Corresponding author
Cavid Mammadov
Department of Periodontology, Faculty of Dentistry, Ankara University, Ankara, Turkey
Department of Periodontology, Faculty of Dentistry, Ankara University, Ankara, Turkey
Tob. Induc. Dis. 2018;16(Suppl 3):A34
KEYWORDS
ABSTRACT
Objective:
The aim of this study was to identify probable intermediate biomarkers of disturbed pathways and their link between smoking.
Methods:
Un-stimulated whole saliva and serum samples were collected from a total of 30 systemically healthy participants with periodontally healthy smokers (S) (n=15) and non-smokers (n=15). Periodontal indices (plaque index, gingival index, probing depth, bleeding on probing, clinical attachment level) were recorded to confirm periodontal health. Saliva was purified, and a total of 28 amino acids and metabolites were analyzed by liquid chromatography-mass spectrometry (LC-MS/MS). Smoking status was validated measuring serum cotinine levels. Intergroup comparisons were assessed using the Mann Whitney U test.
Results:
When 28 amino acids were evaluated, smokers had statistically significantly higher cystathionine levels than non-smokers (p<0.05).
Conclusions:
Saliva cystathionine is associated with smoking in periodontally healthy individuals, and is possibly related to altered sulfuration pathway.
The aim of this study was to identify probable intermediate biomarkers of disturbed pathways and their link between smoking.
Methods:
Un-stimulated whole saliva and serum samples were collected from a total of 30 systemically healthy participants with periodontally healthy smokers (S) (n=15) and non-smokers (n=15). Periodontal indices (plaque index, gingival index, probing depth, bleeding on probing, clinical attachment level) were recorded to confirm periodontal health. Saliva was purified, and a total of 28 amino acids and metabolites were analyzed by liquid chromatography-mass spectrometry (LC-MS/MS). Smoking status was validated measuring serum cotinine levels. Intergroup comparisons were assessed using the Mann Whitney U test.
Results:
When 28 amino acids were evaluated, smokers had statistically significantly higher cystathionine levels than non-smokers (p<0.05).
Conclusions:
Saliva cystathionine is associated with smoking in periodontally healthy individuals, and is possibly related to altered sulfuration pathway.
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| eISSN: | 1617-9625 |
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