Objective:
Smoking and drinking are risks not only of oral cancer but also of the onset and death of cancer as a whole. In this study, we investigated the effects of smoking and drinking on the onset of oral mucosal disease and examined the relationship with lifestyle diseases (hypertension, dyslipidemia, diabetes) and BMI. Furthermore, the characteristics in Gumma prefecture compared with the whole country were clarified.

Methods:
1105 subjects who were able to conduct detailed examination among patients who underwent our department from January 2010 to December 2016 were targeted. It was classified into each group diagnosed as oral squamous cell carcinoma (OSCC), High-grade dysplasia and carcinoma in situ(H-dys･CIS), oral lichen planus (OLP) and the control group. The questionnaire and medical records described at the time of the first visit to the reference, oral mucosal disease onset and smoking and drinking, lifestyle-related diseases morbidity, were studied retrospectively the relationship of BMI.

Results:
Age, diabetes mellitus, Brinkman Index was a risk factor for onset in the OSCC group. Observed significant increase in odds ratio of 3.32 in the group which performs both smoking and drinking in men, became more diabetes joins the 12.51 high odds ratio. In addition, the risk increased significantly as the Brinkman Index increased, indicating a correlation between cumulative smoking dose and oral carcinogenesis. Gunma Prefecture, is the latest of statistics is a nationwide first place male smoking rates, may contribute significantly to the oral cancer incidence has been suggested.

Conclusions:
In the group with both smoking and drinking habits, the risk of developing oral cancer significantly increases. Also, the risk is further increased by the factor of diabetes mellitus. There is a dose-response relationship between smoking and the risk of developing oral cancer. In Gunma prefecture, high smoking rate may be involved in the development of oral cancer.