REVIEW PAPER
Sensory properties of menthol and smoking topography
 
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1
Center for Tobacco Products, Food and Drug Administration from the National Cancer Institute, NIH, USA
 
2
Freelance writer, Charlottesville, USA
 
3
Center for Tobacco Products, Food and Drug Administration, Rockville, USA
 
 
Publication date: 2011-05-23
 
 
Corresponding author
Allison C. Hoffman
Center for Tobacco Products, Food and Drug Administration, Rockville, MD 20850, USA
 
 
Tobacco Induced Diseases 2011;9(Suppl 1):S3
 
KEYWORDS
ABSTRACT
Although there is a great deal known about menthol as a flavoring agent in foods and confections, less is known about the particular sensory properties of menthol cigarette smoke. Similarly, although smoking topography (the unique way an individual smokes a cigarette) has been well studied using non-menthol cigarettes, there is relatively less known about how menthol affects smoking behavior. The objective of this review is to assess the sensory properties of menthol tobacco smoke, and smoking topography associated with menthol cigarettes. The cooling, analgesic, taste, and respiratory effects of menthol are well established, and studies have indicated that menthol’s sensory attributes can have an influence on the positive, or rewarding, properties associated smoking, including ratings of satisfaction, taste, perceived smoothness, and perceived irritation. Despite these sensory properties, the data regarding menthol’s effect on smoking topography are inconsistent. Many of the topography studies have limitations due to various methodological issues.
 
REFERENCES (47)
1.
Harris B: Menthol: a review of its thermoreceptor interactions and their therapeutic applications. International Journal of Aromatherapy. 2006, 16 (3-4): 117-131. 10.1016/j.ijat.2006.09.010.
 
2.
Ahijevych K, Garrett BE: Menthol pharmacology and its potential impact on cigarette smoking behavior. Nicotine and Tobacco Research. 2004, 6 (suppl 1): S17-S28. 10.1080/14622200310001649469.
 
3.
Dessirier JM, O’Mahony M, et al: Oral irritant properties of menthol: sensitizing and desensitizing effects of repeated application and cross-desensitization to nicotine. Physiology and Behavior. 2001, 73 (1-2): 25-36. 10.1016/S0031-9384(01)00431-0.
 
4.
Eccles R, Jones AS: The effect of menthol on nasal resistance to air flow. The Journal of Laryngology and Otology. 1983, 97 (8): 705-709.
 
5.
Kuhn FJP, Kuhn C, et al: Inhibition of TRPM8 by icilin distinct from desensiti¬zation induced by menthol and menthol derivatives. Journal of Biological Chemistry. 2009, 284 (7): 4102-4111. 10.1074/jbc.M806651200.
 
6.
McKemy DD: How cold is it? TRPM8 and TRPA1 in the molecular logic of cold sensation. Mol Pain. 2005, 1: 16-10.1186/1744-8069-1-16.
 
7.
Katsura H, Tsuzuki K, Noguchi K, Masafumi Sakagami: Differential Expression of Capsaicin-, Menthol-, and Mustard Oil-Sensitive Receptors in Naive Rat Geniculate Ganglion Neurons. Chem. Senses. 2006, 31 (7): 681-688. 10.1093/chemse/bjl009.
 
8.
Eccles R: Menthol and related cooling compounds. Journal of Pharmarcy and Pharmacology. 1994, 46 (8): 618-630. 10.1111/j.2042-7158.1994.tb03871.x.
 
9.
Campero M, Baumann TK, et al: Human cutaneous c fibres activated by cooling, heating, and menthol. Journal of Physiology. 2009, 587 (23): 5633-5652. 10.1113/jphysiol.2009.176040.
 
10.
Ferris Wayne, Connolly GN: Application, function, and effects of menthol in cigarettes: a survey of tobacco industry documents. Nicotine and Tobacco Research. 2004, 6 (suppl 1): S43-S54.
 
11.
Galeotti N, Di Cesare Mannelli, et al: Menthol: a natural analgesic compound. Neuroscience Letters. 2002, 322 (3): 145-148. 10.1016/S0304-3940(01)02527-7.
 
12.
Sherkheli MA, Gisselmann G, et al: Menthol derivative WS-12 selectively activates transient receptor potential melastatin-8 (TRPM8) ion channels. Pakistan Journal of Pharmaceutical Sciences. 2008, 21 (4): 370-378.
 
13.
Sant’Ambrogio FB, Anderson JW, et al: Effect of l-menthol on laryngeal receptors. Journal of Applied Physiology. 1991, 70 (2): 788-793.
 
14.
Sekizawa SI, Tsubone H, et al: Nasal receptors responding to cold and l-menthol airflow in the guinea pig. Respiration Physiology. 1996, 103 (3): 211-219. 10.1016/0034-5687(95)00091-7.
 
15.
Eccles R, Jawad MS, et al: The effects of oral administration of (-)-menthol on nasal resistance to airflow and nasal sensation of airflow in subjects suffering from nasal congestion associated with the common cold. Journal of Pharmacy and Pharmacology. 1990, 42 (9): 652-654. 10.1111/j.2042-7158.1990.tb06625.x.
 
16.
Eccles R, Jawad MSM, et al: The effects of L-Menthol on nasal resistance to air-flow and nasal sensation of air-flow in human volunteers suffering from acute upper respiratory-tract infection. Journal of Physiology-London. 1989, 417: P131.
 
17.
Houghton TM, Beardsmore CS: The effect of menthol on nasal airflow, perception of nasal patency, and cough receptor sensitivity in children aged 10 and 11 years. Thorax. 1998, 53 (suppl 4): A9.
 
18.
Nishino T, Tagaito Y, et al: Nasal inhalation of l-menthol reduces respiratory discomfort associated with loaded breathing. American Journal of Respiratory and Critical Care Medicine. 1997, 156 (1): 309-313.
 
19.
Orani GP, Anderson JW, et al: Upper airway cooling and l-menthol reduce ventilation in the guinea pig. Journal of Applied Physiology. 1991, 70 (5): 2080-2086.
 
20.
Sant’Ambrogio FB, Anderson JW, et al: Menthol in the upper airway depresses ventilation in newborn dogs. Respiration Physiology. 1992, 89 (3): 299-307. 10.1016/0034-5687(92)90088-E.
 
21.
Sloan A, De Cort SC, et al: Prolongation of breath-hold time following treatment with an L-menthol lozenge in healthy man. Journal of Physiology. 1993, 473: 53P.
 
22.
Wright CE, Laude EA, et al: Capsaicin and neurokinin A-induced bronchoconstriction in the anaesthetised guinea-pig: evidence for a direct action of menthol on isolated bronchial smooth muscle. British Journal of Pharmacology. 1997, 121 (8): 1645-1650. 10.1038/sj.bjp.0701319.
 
23.
Ito S, Kume H, et al: Inhibition by the cold receptor agonists menthol and icilin of airway smooth muscle contraction. Pulmonary Pharmacology and Therapeutics. 2008, 21 (5): 812-817. 10.1016/j.pupt.2008.07.001.
 
24.
Laude EA, Morice AH, et al: The antitussive effects of menthol, camphor and cineole in conscious guinea-pigs. Pulmonary Pharmacology. 1994, 7 (3): 179-184. 10.1006/pulp.1994.1021.
 
25.
Green BG, Schullery MT: Stimulation of bitterness by capsaicin and menthol: differences between lingual areas innervated by the glossopharyngeal and chorda tympani nerves. Chemical Senses. 2003, 28 (1): 45-55. 10.1093/chemse/28.1.45.
 
26.
Duner-Engstrom M, Larsson O, et al: Effect of nicotine chewing gum on salivary secretion. Swedish Dental Journal. 1986, 10 (3): 93-96.
 
27.
Clark PI, Gautam S, et al: Effect of menthol cigarettes on biochemical markers of smoke exposure among black and white smokers. Chest. 1996, 110 (5): 1194-1198. 10.1378/chest.110.5.1194.
 
28.
Hymowitz N, Mouton C, Edkholdt H: Menthol cigarette smoking in African Americans and Whites. Tobacco Control. 1995, 4: 194-195. 10.1136/tc.4.2.194b.
 
29.
Levin ED, Behm F, et al: The use of flavor in cigarette substitutes. Drug and Alcohol Dependence. 1990, 26 (2): 155-160. 10.1016/0376-8716(90)90122-U.
 
30.
Kreslake JM, Wayne GF, et al: The menthol smoker: tobacco industry research on consumer sensory perception of menthol cigarettes and its role in smoking behavior. Nicotine and Tobacco Research. 2008, 10 (4): 705-715. 10.1080/14622200801979134.
 
31.
Ahijevych K, Gillespie J, et al: Menthol and nonmenthol cigarettes and smoke exposure in black and white women. Pharmacology Biochemistry, and Behavior. 1996, 53 (2): 355-360. 10.1016/0091-3057(95)02034-9.
 
32.
Ahijevych K, Parsley LA: Smoke constituent exposure and stage of change in black and white women cigarette smokers. Addictive Behaviors. 1999, 24 (1): 115-120. 10.1016/S0306-4603(98)00031-8.
 
33.
Jarvik ME, Tashkin DP, et al: Mentholated cigarettes decrease puff volume of smoke and increase carbon monoxide absorption. Physiology and Behavior. 1994, 56 (3): 563-570. 10.1016/0031-9384(94)90302-6.
 
34.
McCarthy WJ, Caskey NH, et al: Menthol vs. nonmenthol cigarettes: effects on smoking behavior. American Journal of Public Health. 1995, 85 (1): 67-72. 10.2105/AJPH.85.1.67.
 
35.
Miller GE, Jarvik ME, et al: Cigarette mentholation increases smokers’ exhaled carbon monoxide levels. Experimental and Clinical Psychopharmacology. 1994, 2 (2): 154-160. 10.1037/1064-1297.2.2.154.
 
36.
Strasser AA, Milaiyandi V, et al: An association of CYP2A6 genotype and smoking topography. Nicotine and Tobacco Research. 2007, 9 (4): 511-518. 10.1080/14622200701239605.
 
37.
Nil R, Battig K: Separate effects of cigarette smoke yield and smoke taste on smoking behavior. Psychopharmacology (Berl). 1989, 99 (1): 54-59. 10.1007/BF00634452.
 
38.
Caskey NH, Jarvik ME, et al: Rapid smoking of menthol and nonmenthol cigarettes by black and white smokers. Pharmacology Biochemistry, and Behavior. 1993, 46 (2): 259-263. 10.1016/0091-3057(93)90350-3.
 
39.
Moolchan ET, Hudson DL, et al: Heart rate and blood pressure responses to tobacco smoking among African-American adolescents. Journal of the National Medical Association. 2004, 96 (6): 767-771.
 
40.
Sidney S, Tekawa I, et al: Mentholated cigarette use among multiphasic examinees, 1979–86. American Journal of Public Health. 1989, 79 (10): 1415-1416. 10.2105/AJPH.79.10.1415.
 
41.
Pickworth WB, Moolchan ET, et al: Sensory and physiologic effects of menthol and non-menthol cigarettes with differing nicotine delivery. Pharmacology Biochemistry, and Behavior. 2002, 71 (1-2): 55-61. 10.1016/S0091-3057(01)00623-2.
 
42.
Garten S, Falkner RV: Role of mentholated cigarettes in increased nicotine dependence and greater risk of tobacco-attributable disease. Preventive Medicine. 2004, 38 (6): 793-798. 10.1016/j.ypmed.2004.01.019.
 
43.
Celebucki CC, Wayne GF, et al: Characterization of measured menthol in 48 U.S. cigarette sub-brands. Nicotine and Tobacco Research. 2005, 7 (4): 523-531. 10.1080/14622200500186270.
 
44.
Pritchard WS, Houlihan ME, et al: Little evidence that “denicotinized” menthol cigarettes have pharmacological effects: an EEG/heart-rate/subjective-response study. Psychopharmacology (Berl). 1999, 143 (3): 273-279. 10.1007/s002130050947.
 
45.
Rose JE, Behm FM: Extinguishing the rewarding value of smoke cues: pharmacological and behavioral treatments. Nicotine and Tobacco Research. 2004, 6 (3): 523-532. 10.1080/14622200410001696501.
 
46.
McKemy DD: TRPM8: The Cold and Menthol Receptor. TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades. Edited by: Liedtke WB, Heller S. 2007, Boca Raton (FL): CRC Press, Chapter 13.Frontiers in Neuroscience.
 
47.
Ahijevych K, Garrett BE: The role of menthol in cigarettes as a reinforcer of smoking behavior. Nicotine and Tobacco Research. 2010, S110-6. 10.1093/ntr/ntq203. Suppl 2.
 
 
CITATIONS (26):
1.
Heterogeneous deposition of regular and mentholated little cigar smoke in the lungs of Sprague-Dawley rats
Kaisen Lin, Christopher Wallis, Emily Wong, Patricia Edwards, Austin Cole, Winkle Van, Anthony Wexler
Particle and Fibre Toxicology
 
2.
A Method to Amend Cigarettes With Menthol for Use in Research
Kia J Jackson, Megan J Schroeder, Jiu Ai, Kenneth M Taylor, Olusola Oniyide, Lauren C Viray, Carson Smith, Bartosz Koszowski, Jenny M Butler, Wallace B Pickworth
Nicotine and Tobacco Research
 
3.
Application of therate‐all‐that‐applymethod to explore the perception of flavours provided by e‐cigarettes: Importance of 1.3‐propanediol
Zeineb Nhouchi, Justine Belay, Farnaz Hanaei, Nadine Vallet
Flavour and Fragrance Journal
 
4.
Metabolomic profiles of current cigarette smokers
Ping‐Ching Hsu, Renny S. Lan, Theodore M. Brasky, Catalin Marian, Amrita K. Cheema, Habtom W. Ressom, Christopher A. Loffredo, Wallace B. Pickworth, Peter G. Shields
Molecular Carcinogenesis
 
5.
Substitutability of menthol cigarette alternatives: a clinical trial
Andrea C Villanti, Alice Hinton, Jonathan A Schulz, Tyler G Erath, Toral Mehta, Derek Reed, Jennifer Tidey, Michael Businelle, Theodore L Wagener
Tobacco Control
 
6.
Racial Disparities in Cigarette Smoking Behaviors and Differences Stratified by Metropolitan Area of Residence
Rony F. Arauz, Margaret Mayer, Carolyn Reyes-Guzman, Bríd M. Ryan
International Journal of Environmental Research and Public Health
 
7.
The Impact of Menthol Cigarette Flavor in the U.S.: Cigarette and ENDS Transitions by Sociodemographic Group
Andrew F. Brouwer, Jihyoun Jeon, Steven F. Cook, Bukola Usidame, Jana L. Hirschtick, Evelyn Jimenez-Mendoza, Ritesh Mistry, Nancy L. Fleischer, Theodore R. Holford, David Mendez, David T. Levy, Rafael Meza
American Journal of Preventive Medicine
 
8.
Role of sweet and other flavours in liking and disliking of electronic cigarettes
Hyoshin Kim, Juyun Lim, Stephanie S Buehler, Marielle C Brinkman, Nathan M Johnson, Laura Wilson, Kandice S Cross, Pamela I Clark
Tobacco Control
 
9.
Effect of e-liquid flavor on electronic cigarette topography and consumption behavior in a 2-week natural environment switching study
R. J. Robinson, E. C. Hensel, A. A. al-Olayan, J. M. Nonnemaker, Y. O. Lee, Rachel N Cassidy
PLOS ONE
 
10.
Assessment of the abuse liability of three menthol Vuse Solo electronic cigarettes relative to combustible cigarettes and nicotine gum
Mitchell F. Stiles, Leanne R. Campbell, Tao Jin, Donald W. Graff, Reginald V. Fant, Jack E. Henningfield
Psychopharmacology
 
11.
Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants
Daniel N. Willis, Boyi Liu, Michael A. Ha, Sven‐Eric Jordt, John B. Morris
The FASEB Journal
 
12.
An inventory of methods suitable to assess additive-induced characterising flavours of tobacco products
Reinskje Talhout, Suzanne van de Nobelen, Anne S. Kienhuis
Drug and Alcohol Dependence
 
13.
Flavour preferences in youth versus adults: a review
Allison C Hoffman, Raydel Valdes Salgado, Carolyn Dresler, Rachel Williams Faller, Christopher Bartlett
Tobacco Control
 
14.
The Effects of Changes in Cigarette Menthol Content on Acute Nicotine Pharmacology and Smoking Topography
Hristina Dimova, Megan J Schroeder, Wallace B Pickworth, Jia Wang, Olusola Oniyide, Lauren C Viray, Carson Smith, Bartosz Koszowski, Kia J Jackson
Nicotine and Tobacco Research
 
15.
Menthol Cigarettes, Race/Ethnicity, and Biomarkers of Tobacco Use in U.S. Adults: The 1999–2010 National Health and Nutrition Examination Survey (NHANES)
Miranda R. Jones, Benjamin J. Apelberg, Maria Tellez-Plaza, Jonathan M. Samet, Ana Navas-Acien
Cancer Epidemiology, Biomarkers & Prevention
 
16.
Lack of effect of menthol level and type on smokers’ estimated mouth level exposures to tar and nicotine and perceived sensory characteristics of cigarette smoke
Madeleine Ashley, Mike Dixon, Ajit Sisodiya, Krishna Prasad
Regulatory Toxicology and Pharmacology
 
17.
(-)-Menthol-β-cyclodextrin inclusion complex production and characterization
Guangyong Zhu, Zuobing Xiao, Rujun Zhou, Junhua Liu, Guangxu Zhu, Xiongjian Zheng
Polish Journal of Chemical Technology
 
18.
Menthol Smokers: Metabolomic Profiling and Smoking Behavior
Ping-Ching Hsu, Renny S. Lan, Theodore M. Brasky, Catalin Marian, Amrita K. Cheema, Habtom W. Ressom, Christopher A. Loffredo, Wallace B. Pickworth, Peter G. Shields
Cancer Epidemiology, Biomarkers & Prevention
 
19.
Menthol cigarette use in young adult smokers with severe mental illnesses
Mary F Brunette, Joelle C Ferron, Pamela Geiger, Andrea C Villanti
Nicotine & Tobacco Research
 
20.
Effects of liquid nicotine concentration and flavour on the acceptability of electronic nicotine delivery systems (ENDS) among people who smoke participating in a randomised controlled trial to reduce cigarette consumption
Jessica Yingst, Vishal Midya, Augustus White, Jonathan Foulds, Caroline O Cobb, Susan Veldheer, Miao-Shan Yen, Thomas Eissenberg
Tobacco Control
 
21.
Differences in Subjective Experiences to First Use of Menthol and Nonmenthol Cigarettes in a National Sample of Young Adult Cigarette Smokers
Joanne D’Silva, Amy M Cohn, Amanda L Johnson, Andrea C Villanti
Nicotine & Tobacco Research
 
22.
The Influence of Puff Characteristics, Nicotine Dependence, and Rate of Nicotine Metabolism on Daily Nicotine Exposure in African American Smokers
Kathryn C. Ross, Delia A. Dempsey, Gideon St. Helen, Kevin Delucchi, Neal L. Benowitz
Cancer Epidemiology, Biomarkers & Prevention
 
23.
The Biological Impact of Menthol on Tobacco Dependence
Robert J Wickham
Nicotine & Tobacco Research
 
24.
Differences in Smoking Topography and Subjective Responses to Smoking Among African American and White Menthol and Non-Menthol Smokers
Tommy Gunawan, Laura M Juliano
Nicotine & Tobacco Research
 
25.
Menthol cigarette smoking is associated with greater subjective reward, satisfaction, and “throat hit”, but not greater behavioral economic demand
Amy M. Cohn, Ollie Ganz, Ashley A. Dennhardt, James G. Murphy, Sarah Ehlke, Sarah Cha, Amanda L. Graham
Addictive Behaviors
 
26.
Effect of menthol on nicotine intake and relapse vulnerability in a rat model of concurrent intravenous menthol/nicotine self-administration
Tanseli Nesil, Syeda Narmeen, Anousheh Bakhti-Suroosh, Wendy J. Lynch
Psychopharmacology
 
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