Introduction:
High rates of smoking in religious leaders regarded as a challenge in the campaign and control tobacco consumption. They are the role model for society and society that people respect and obey them. Religious principles and cultural characteristics are one of the key factors in creating a health promotion structure. by using religion as the driving force in controlling tobacco consumption especially creating a turning point that began among religious leaders that are the prototype of the Muslim society.

Objectives:
This qualitative research aimed to investigate smoking cessation among Islamic leaders in Pattani Province.

Methods:
Purposive sampling was used to select a sample of 19 religious leaders from mosques. Data was collected using a questionnaire administered during semi-structured in-depth interviews and the data were analyzed using qualitative content analysis.

Results:
It was found that the religious leaders give up smoking by adjusting their mind-set and derived support from, for instance, nurses and their family. They read and listened to the Koran and religious texts repeatedly. Moreover, they applied the words of the Koran to their health problems. Furthermore, their fear of smoking-related disease helped them to modify their behavior and to completely give up smoking. They also sought help by consulting nurses, and learned the skills necessary to resist tobacco, as well as exercising and using herbal remedies to assist the smoking cessation process.

Conclusion(s):
The key reasons for them to success quit smoking were health problem and religion practice.