The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
2
Division of Occupational Health Medicine, Department of Biopathology and Imaging Diagnostics,
University of Rome, Tor Vergata, School of Medicine, Rome, Italy
3
Department of Medical Genetics, City of Hope National Medical Center, Duarte, California
4
Institute of Obstetrics and Gynecology, University of Rome La Sapienza, School of Medicine,
Rome, Italy
5
Division of Medical Statistics, Department of Biopathology and Imaging Diagnostics,
University of Rome Tor Vergata, School of Medicine, Rome, Italy
Submission date: 2002-01-17
Acceptance date: 2002-03-15
Publication date: 2002-03-15
Corresponding author
F Gloria-Bottini
Dipartimento di Biopatologia e Diagnostica per Immagini, Facolta di Medicina Via della Ricerca Scientifica, 1
00133, Roma, Italy
A prospective study on two samples of consecutive puerperae (total n° 667) from two populations
has been carried out in order to investigate the possible effect of smoking habit on relationship between
fertility and haptoglobin phenotype.
In both populations the negative association previously reported between age of pueperae and
Haptoglobin *1/*1 phenotype is present only in women with smoking habit pointing to an interaction between
Hp and smoke on human fertility. This suggests that the effects of smoke on fertility are dependent
on the Hp phenotype.
REFERENCES(19)
1.
Bottini N, Gimelfarb A, Gloria-Bottini F, La Torre M, Lucarelli P, Lucarini N: Haptoglobin genotype and natural fertility in humans. Fertility and Sterility. 1999, 72: 1-4. 10.1016/S0015-0282(99)00153-3.
Shima M, Adachi M: Effects of environmental tobacco smoke on serum levels of acute phase proteins in school children. Preventive Medicine. 1996, 25: 617-624. 10.1006/pmed.1996.0097.
Bottini E, Carapella E, Scacchi R, Lucarini N, Gloria-Bottini F, Pascone R, Bonci E, Maggioni G: Serum haptoglobin appearance during neonatal period is associated with acid phosphatase (ACP1) phenotype. Early Human Development. 1985, 10: 237-243. 10.1016/0378-3782(85)90054-4.
Gimelfarb A, Bottini E: Age difference between distribution of genotypes among pregmant women: evidence of fertility selection. Genetic Research. 1999, 53: 207-214. 10.1017/S0016672300028184.
Smithies O: Zone electrophoresis in starch gels: grouped variations in the serum proteins of normal human adults. Biochemistry Journal. 1955, 61: 629-641.
Miller YI, Altamenova SM, Shaklai N: Oxidation of low density lipoprotein by hemoglobin stems from a heme-initiated globin radical: antioxidant role of haptoglobin. Biochemistry. 1997, 36: 12189-12198. 10.1021/bi970258a.
Berkova N, Lemay A, De Grandprè P, Goupil S, Maheux R: Immunoblot detection of decreased antibodies to haptoglobin-like protein in the serum of infertile women with or without endometriosis. Biology of Reproduction. 1997, 57: 178-185. 10.1095/biolreprod57.1.178.
Berkova N, Lemay A, Dresser DW, Fontaine JY, Kerizit , Goupil S: Haptoglobin is present in human endometrium and shows elevated levels in the decidua during pregnancy. Molecular Human Reproduction. 2001, 7: 747-754. 10.1093/molehr/7.8.747.
Bottini E, Gloria-Bottini F, La Torre M, Lucarini N: The genetics of signal transduction and the effect of smoking on intrauterine growth. International Journal of Epidemiology. 2001, 30: 400-402. 10.1093/ije/30.2.400.
Hong YC, Kim H, Im MW, Lee KH, Woo BH, Christiani DC: Maternal genetic effects on neonatal susceptibility to oxidative damage from environmental tobacco smoke. Journal National Cancer Institute. 2001, 93: 645-10.1093/jnci/93.8.645.
Smoking and the correlation between birth weight and placental weight. Evidence of interaction with maternal haptoglobin phenotype F. Gloria-Bottini, E. Bottini European Journal of Obstetrics & Gynecology and Reproductive Biology
Haptoglobin phenotypes andin vitrofertilization treatment outcomes Amir Weiss, David Ozeri, Ronit Beck-Fruchter, Michal Lavee, Yoel Geslevich, Andrew P. Levy Systems Biology in Reproductive Medicine
The ADA∗2 allele of the adenosine deaminase gene (20q13.11) and recurrent spontaneous abortions: an age-dependent association Daniela Nunes, Lígia Spegiorin, Mattos de, Antonio Oliani, Denise Vaz-Oliani, Mattos de Clinics
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