Introduction:
Public interest in e-cigarette has increased rapidly, especially among university students. University students aged 18-24 years belongs to the group of young adults who are the most vulnerable group attracted to e-cigarette. E-cigarette use can be influenced by various things, one of the reasons is the perception of advantages and disadvantages of e-cigarette.

Objectives:
The purpose of this study is to assess the relationship between perception of advantages and disadvantages of e-cigarette use on frequency of e-cigarette use among students at University of Indonesia. The results can be used to make regulations regarding the use of e-cigarettes among university students to achieve tobacco-free educational institution.

Methods:
This research was conducted at University of Indonesia between June 2018 and July 2019. The research used cross-sectional design and purposive sampling technique. The research questionnaire was distributed to 104 University of Indonesia students aged 18-24 years who met the eligibility criteria. Univar ate analysis was performed to see the distribution of the e-cigarette users and the chi-square test was performed to assess the relationship between variables.

Results:
About half (50%) of the respondents use e-cigarettes routinely and the other half not using it routinely. The majority of respondents have a positive perception of the definition, contents, advantages, and disadvantages of e-cigarette use. Data showed a significant association between the perception of the contents of e-cigarette with the frequency of e-cigarette use (p<0,05)

Conclusion(s):
This research significantly showed that the University of Indonesia students who use e-cigarette more routinely have the perception that e-cigarette is dangerous. This is thought to be caused by students commonly use e-cigarette because of mere curiosity without any intention to cease smoking. It showed that the regulations related to e-cigarette from the authorities are important in order to reduce the frequency of e-cigarette use or even the number of e-cigarette users among university students.